Greatest Antagonists in Gaming or How I Learned to Stop Worrying and Love Villainy

We discuss the biggest, best, most badass villains, and what makes (or fails to make) a great/memorable foe in games.

Potential spoilers:

Batman: Arkham (series), Bioshock (series), Bloodborne, Borderlands (series), Breath of Fire (series), Chrono Trigger, Dark Souls, Doom (series), Dragonage (series), Farcry 3, Final Fantasy (series), Half-Life (series), Infamous 1, Legend of Zelda (series), Lufia (series), Mario Bros. (series), Portal, Resident Evil (series), Secret of Evermore, Silent Hill (series), Telltale: Game of Thrones, Wolfenstein (series)

Other: Silence of the Lambs